TAMpering with Toll-like Receptor Signaling
نویسنده
چکیده
Toll-like receptors (TLRs) provoke a profound inflammatory response during host defense and must be controlled in order to avoid autoimmune and inflammatory diseases. In this issue, Rothlin et al. (2007) uncover a complex negative feedback mechanism to limit TLR signaling involving the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, which induce expression of the inhibitory proteins SOCS1 and SOCS3.
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عنوان ژورنال:
- Cell
دوره 131 شماره
صفحات -
تاریخ انتشار 2007